Leuprolide Acetate

CAS No. 74381-53-6

Leuprolide Acetate ( Leuprorelin acetate )

Catalog No. M19932 CAS No. 74381-53-6

Leuprolide is an agonist at pituitary GnRH receptors. Leuprorelin is a gonadotropin-releasing hormone (GnRH) analog used to treat a wide range of sex hormone-related disorders including advanced prostatic cancer endometriosis and precocious puberty.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 76 In Stock
10MG 108 In Stock
50MG 179 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Leuprolide Acetate
  • Note
    Research use only not for human use.
  • Brief Description
    Leuprolide is an agonist at pituitary GnRH receptors. Leuprorelin is a gonadotropin-releasing hormone (GnRH) analog used to treat a wide range of sex hormone-related disorders including advanced prostatic cancer endometriosis and precocious puberty.
  • Description
    Leuprolide is an agonist at pituitary GnRH receptors. Leuprorelin is a gonadotropin-releasing hormone (GnRH) analog used to treat a wide range of sex hormone-related disorders including advanced prostatic cancer endometriosis and precocious puberty. Leuprorelin acts primarily on the anterior pituitary inducing a transient early rise in gonadotrophin release. With continued use Leuprorelin causes pituitary desensitization and/or down-regulation leading to suppressed circulating levels of gonadotrophins and sex hormones.By interrupting the normal pulsatile stimulation of and thus desensitizing the GnRH receptors it indirectly downregulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) leading to hypogonadism and thus a dramatic reduction in estradiol and testosterone levels in both sexes.
  • Synonyms
    Leuprorelin acetate
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    GNRHR
  • Research Area
    Cancer
  • Indication
    Endometriosis

Chemical Information

  • CAS Number
    74381-53-6
  • Formula Weight
    1269.45
  • Molecular Formula
    C59H84N16O12. C2H4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 40 mg/mL;Water: 60 mg/mL
  • SMILES
    CC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1
  • Chemical Name
    Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt acetate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wilson AC et al. Leuprolide acetate: a drug of diverse clinical applications. Expert Opin Investig Drugs. 2007 Nov;16(11):1851-63.
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