Leuprolide Acetate
CAS No. 74381-53-6
Leuprolide Acetate ( Leuprorelin acetate )
Catalog No. M19932 CAS No. 74381-53-6
Leuprolide is an agonist at pituitary GnRH receptors. Leuprorelin is a gonadotropin-releasing hormone (GnRH) analog used to treat a wide range of sex hormone-related disorders including advanced prostatic cancer endometriosis and precocious puberty.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 76 | In Stock |
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10MG | 108 | In Stock |
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50MG | 179 | In Stock |
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100MG | Get Quote | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameLeuprolide Acetate
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NoteResearch use only not for human use.
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Brief DescriptionLeuprolide is an agonist at pituitary GnRH receptors. Leuprorelin is a gonadotropin-releasing hormone (GnRH) analog used to treat a wide range of sex hormone-related disorders including advanced prostatic cancer endometriosis and precocious puberty.
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DescriptionLeuprolide is an agonist at pituitary GnRH receptors. Leuprorelin is a gonadotropin-releasing hormone (GnRH) analog used to treat a wide range of sex hormone-related disorders including advanced prostatic cancer endometriosis and precocious puberty. Leuprorelin acts primarily on the anterior pituitary inducing a transient early rise in gonadotrophin release. With continued use Leuprorelin causes pituitary desensitization and/or down-regulation leading to suppressed circulating levels of gonadotrophins and sex hormones.By interrupting the normal pulsatile stimulation of and thus desensitizing the GnRH receptors it indirectly downregulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) leading to hypogonadism and thus a dramatic reduction in estradiol and testosterone levels in both sexes.
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SynonymsLeuprorelin acetate
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PathwayOthers
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TargetOther Targets
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RecptorGNRHR
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Research AreaCancer
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IndicationEndometriosis
Chemical Information
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CAS Number74381-53-6
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Formula Weight1269.45
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Molecular FormulaC59H84N16O12. C2H4O2
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Purity>98% (HPLC)
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SolubilityDMSO: 40 mg/mL;Water: 60 mg/mL
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SMILESCC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1
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Chemical NamePyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt acetate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wilson AC et al. Leuprolide acetate: a drug of diverse clinical applications. Expert Opin Investig Drugs. 2007 Nov;16(11):1851-63.
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